selected publications

Dannenmaier, S., Desroches Altamirano, C., Schuler, L., Zhang, Y., Hummel, J., Milanov, M., Oeljeklaus, S., Koch, H.G., Rospert, S., Alberti, S., et al. (2021). Quantitative proteomics identifies the universally conserved ATPase Ola1p as a positive regulator of heat shock response in Saccharomyces cerevisiae. J Biol Chem, 101050.

Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wolfle T, Rodnina MV, Schwappach B, Rospert S (2021) Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast. Nat Commun 12: 782. https://www.nature.com/articles/s41467-021-20981-3

Zhang Y, Valentin Gese G, Conz C, Lapouge K, Kopp J, Wolfle T, Rospert S, Sinning I (2020) The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun 11: 1504. 10.1038/s41467-020-15313-w

Gribling-Burrer AS, Chiabudini M, Zhang Y, Qiu Z, Scazzari M, Wolfle T, Wohlwend D, Rospert S (2019) A dual role of the ribosome-bound chaperones RAC/Ssb in maintaining the fidelity of translation termination. Nucleic Acids Res 7018-7034. 10.1093/nar/gkz334

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O’Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pallman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL (2019) Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation. Cell Metab 30: 352-363 e358. 10.1016/j.cmet.2019.05.003

Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, Pulido P, Ramos C, De Los Rios P, Rospert S, Rosenzweig R, Sahi C, Taipale M, Tomiczek B, Ushioda R, Young JC, Zimmermann R, Zylicz A, Zylicz M, Craig EA, Marszalek J (2019) Function, evolution, and structure of J-domain proteins. Cell Stress Chaperones 7-15. 10.1007/s12192-018-0948-4

Mudholkar K, Fitzke E, Prinz C, Mayer MP, Rospert S (2017) The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway. Nat Commun 8: 1-14. 10.1038/s41467-017-00635-z

Jank T, Belyi Y, Wirth C, Rospert S, Hu Z, Dengjel J, Tzivelekidis T, Andersen GR, Hunte C, Schlosser A, Aktories K (2017) Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A. J Biol Chem 292: 16014-16023. 10.1074/jbc.M117.801035

Hübscher V, Mudholkar K, Rospert S (2017) The yeast Hsp70 homolog Ssb: a chaperone for general de novo protein folding and a nanny for specific intrinsically disordered protein domains. Curr Genet 63: 9-13. 10.1007/s00294-016-0610-6

Zhang Y, Sinning I, Rospert S (2017) Two chaperones locked in an embrace: Structure and function of the ribosome-associated complex RAC. Nat Struct Mol Biol 24: 611-619. 10.1038/nsmb.3435

Gumiero A, Conz C, Gesé GV, Zhang Y, Weyer FA, Lapouge K, Kappes J, von Plehwe U, Schermann G, Fitzke E, Wölfle T, Fischer T, Rospert S, Sinning I (2016) Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun 7: 1-12. 10.1038/ncomms13563

Hübscher V, Mudholkar K, Chiabudini M, Fitzke E, Wölfle T, Pfeifer D, Drepper F, Warscheid B, Rospert S (2016) The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae. Nucleic Acids Res 44: 5629-5645. 10.1093/nar/gkw168

Zhang Y, Schaffer T, Wölfle T, Fitzke E, Thiel G, Rospert S (2016) Cotranslational intersection between the SRP and GET targeting pathways to the ER of Saccharomyces cerevisiae. Mol Cell Biol 36: 2374-2383. 10.1128/MCB.00131-16