positions

PhD student position (starting from 01.11.2020)

The Rospert lab is looking for a motivated PhD student interested in the field of molecular chaperones and metabolic signaling. The successful candidate will join the team working on the project “partitioning of the Hsp70 Ssb between ribosomes and cytosolic chaperone machineries” within the SFB 1381.

The yeast Hsp70 chaperone Ssb interacts with ribosomes and nascent chains and mediates co-translational protein folding. Ssb is also involved in the post-translational regulation of the central metabolic signaling kinases SNF1 (homolog of human AMPK) and TORC1/Sch9, which control translation in response to environmental changes. We investigate how Ssb partitions between its roles as i) a chaperone involved in de novo protein folding and ii) as a regulator of the cellular response to fluctuating environmental conditions.

For that purpose we combine the power of yeast genetics with a wide range of state-of-the-art biochemical methods such as ribosome profile analysis, phos-tag analysis, chemical crosslinking, native protein assembly purification and functional characterization, and sophisticated in vitro translation experiments. We closely collaborate with experts in mass spectrometry, X-ray crystallography, and single molecule analysis.

For further information see: rospertlab.org/

Please send your application to:

Prof. Dr. S. Rospert

sabine.rospert@biochemie.uni-freiburg.de